Objective To explore the effect of integrated application of multi-mode teaching in presentation-assimilation-discussion (PAD) class of medical microbiology. Methods　A total of 102 2017-batch clinical medical students of Hubei University of Medicine were collected

and the quasi-experimental study was adopted. The experimental class (50 students) was established by setting a PAD class

integrating the use of WeChat public account

Rain Classroom and WJX software during the teaching implement. And traditional mode of teaching was carried out in the control class (52 students). Moreover

the questionnaire survey and the test assessment were applied to compare the teaching effects of the two classes. Results Questionnaire results showed that scores of indicators related to the teaching effectiveness in the experimental group were significantly higher than those in the control group (P<0.01)

and scores of tests in the experimental group were significantly better than those in the control group (P<0.01). The t test was performed by SPSS 20 in the study. Conclusion　The integrated application of multi-mode teaching enriches the teaching mode of PAD class

which fully describes the student-centered concept

and increases students' initiative

participation

as well as students' knowledge mastery and innovation.