Objective　To explore the influence of virtual simulation experiment project on the experimental teaching effect of infectious diseases. Methods　Ten experimental contents were selected

including 3 703 students majoring in clinical five-year program

eight-year program

anesthesia

psychiatry and other majors of Medicine School of Central South University. The teaching effect and students' satisfaction were evaluated through examination and personal questionnaire survey. The measurement data was expressed by (mean ± standard deviation)

the counting data was illustrated by percentage. The rate is compared by Chi-square test

and the difference is statistically significant when P<0.05. Results　All the students took part in the examination of 10 items. Except for item 8

the scores of students in all items had a large variance

with almost same number of high score students and low score students. Learning attitude is closely related to learning effect. Among the students who think it's necessary to learn

20.5% and 53% have excellent learning effect and good learning effect

respectively. Compared with offline experiment teaching

virtual simulation teaching has both advantages and disadvantages

and needs to further improve the satisfaction of students. Conclusion　Virtual simulation teaching of infectious diseases is unable to completely replace offline teaching

and the combination of virtual and reality is more conducive to improving the quality of medical students.