Objective　To explore the application value of case three-dimensional teaching method combined with standardized patient (CTTM+SP) in the clinical clerkship teaching reform of gastrointestinal surgery. Methods A total of 120 students of clinical medicine having clerkship in Binzhou Medical University Hospital were recruited in this study

and they were randomized to the experimental group and the control group

with 60 students in each group. The experimental group took the CTTM+SP teaching method

and the control group adopted the lecture-based learning teaching method. The comprehensive ability of the two groups was evaluated by department graduation examination and satisfaction survey. Results　The examination performance and the satisfaction rate of students in the experimental group were significantly higher than those of the control group (P < 0.05). Conclusion　CTTM+SP teaching method is helpful for the probationers to master the theoretical knowledge of gastrointestinal surgery systematically

improve the clinical thinking ability and the ability to solve practical problems

mobilize the students' learning motivation and interest

and improve the teaching effect of gastrointestinal surgery clinical clerkship.