Objective　To explore the application of micro-lecture system based on ASSURE model in clinical practice teaching of dermatology. Methods　Sixty clinical medicine undergraduate intern doctors in Batch 2014 of Anhui Medical University were randomized into 2 groups

with thirty interns in both experimental group and control group. Micro-lecture system based on ASSURE model teaching method was adopted in experimental group

while traditional teaching method was adopted in control group. At the end of practice

theory test scores and medical record writing was used to evaluate the clinical ability of interns in two groups

and questionnaire survey was conducted to evaluate the satisfaction of interns with the teaching method of micro-lecture system based on ASSURE model. SPSS 16.0 was used for t test. Results　①Theory test scores were higher in experimental group than in control group

with statistically significant differences between the two groups (P<0.05); ②The scores of history of illness

physical examination

treatment plan and the medical record writing were higher in experimental group than in control group (P<0.05); ③At the end of internship

the questionnaire showed that the interns in the experimental group were more recognized for this new way of teaching. Conclusion　Micro-lecture system based on ASSURE model teaching method has achieved better results in the teaching of dermatology

which is worthy of future research and promotion．