Objective　To explore the application of web problem-based learning (WPBL) + case-based learning (CBL) combined with clinical pathways in dermatological nursing teaching. Methods　A total of 120 nurses who practiced in the dermatology department of The First Affiliated Hospital of Air Force Medical University from July 2018 to June 2020 were selected as the research objects. According to the nurse practice period

they were divided into a control group and a study group

with 60 people in each group. The control group used traditional teaching

and the study group used WPBL+CBL combined with clinical pathways for teaching. After the teaching

the two groups of practical nurses were assessed for their theoretical and clinical operational abilities

and the comprehensive abilities of the two groups of practical nurses and their satisfaction with teaching were assessed through questionnaire surveys. SPSS 22.0 was used for t test and ?字2 test. Results　The theoretical and clinical performance assessment results of the study group were better than those of the control group

and the difference was statistically significant (P<0.001). The research group was better than the control group in assessment of improving clinical operation ability

independent problem-solving ability

cultivating teamwork ability

improving self-learning ability

improving ability of presenting and analyzing problems

improving comprehensive analysis ability

cultivating clinical thinking ability and comprehensive ability

with statistical significance (P<0.001). The satisfaction rate of the trainee nurses in the study group was 93.33%

and the satisfaction rate of the trainee nurses in the control group was 31.67%

with statistically significant differences. Conclusion　WPBL+CBL combined with clinical pathways teaching can significantly improve the theoretical and clinical operation ability of dermatology practice nurses

and improve their comprehensive ability and clinical teaching satisfaction rate

which is worthy of application and promotion in clinical nursing teaching.