［］Objective To explore the application values of combination of sonographic grading and FibroScan in liver grafts from brain death donor (DBD). Methods Liver grafts of 37 DBD cases were underwent FibroScan examination and sonographic grading (grade 0 to grade 5). Blood samples were tested preoperatively. For all recipients

abdominal ultrasonography and blood tests were performed preoperatively and daily postoperatively to screen for early allograft dysfunction (EAD). Based upon early allograft function of liver transplantation (LT) recipients

the donors were classified into EAD and early allograft function normal (non-EAD) groups. Statistical analyses were performed to analyze the correlations among controlled attenuation parameter (CAP)

liver stiffness (LS)

liver graft sonographic grading and EAD. Receiver operating curve (ROC) was employed for analyzing the diagnostic accuracy of CAP

LS and sonographic grading in EAD. Results The CAP and LS value of EAD group was obviously higher than that of non-EAD group P＜0.05]. CAP value is an independent influencing factor of EAD. sonographic grading of EAD group was also significantly higher than that of non-EAD group (P=0.003).The area under ROC curve (AUROC) of CAP in EAD was 0.854(P<0.001)

optimal cut-off value 206 dB/m (sensitivity

82.4%; specificity

80%). AUROC of ultrasonic grading 0.807(P=0.002) and optimal cut-off value level 3.5(sensitivity

81.3%;specificity

77.78%). Conclusions FibroScan quantifies fibrosis and steatosis in liver grafts from DBD

combination of FibroScan and sonographic grading can predict postoperative EAD in LT recipients with high sensitivity. FibroScan and sonographic grading may improve the assessments of liver grafts of DBD.