Objective To analyze the left intraventricular pressure differences（LVPDs） and left intraventricular pressure gradients（IVPGs） in patients with hepatitis B cirrhosis with normal cardiac function and to evaluate their clinical value by applying the blood flow vector imaging (VFM) technique. Methods Thirty-nine patients clinically diagnosed with hepatitis B cirrhosis but with normal cardiac function (meets the normal criteria of the 2020 edition of the clinical application guidelines for echocardiography) at the First Hospital of Harbin Medical University from April 2022 to October 2022 were selected and another 31 normal controls were selected. The VFM technique was applied to calculate the IVPDs and IVPGs of left ventricular isovolumic systole (IC)

rapid ejection phase (RE)

isovolumic diastole (IR)

rapid filling phase (RF)

slow filling phase (SF) and atrial systole (AC)

respectively

while the conventional cardiac ultrasound indices were collected

and the differences of the above indices between the two groups of subjects were compared. Results ①AC-IVPD and AC-IVPG were higher in the cirrhotic group than in the standard control group (P < 0.05); ②AC-IVPD and AC-IVPG correlations in the cirrhotic group were positively correlated with the A peak (r = 0.608

0.581

both P < 0.001)

with the mean E/e' (r = 0.495

0.433

both P < 0.01)

negative correlation with E/A (r=-0.535

-0.605

both P < 0.001)

negative correlation with e' septum (r=-0.412

-0.500

both P < 0.01)

and negative correlation with e' left ventricular sidewall (r=-0.374

-0.410

both P < 0.01). Conclusions The VFM technique can detect changes in the left ventricular diastolic pressure gradient from a hemodynamic perspective in patients with hepatitis B cirrhosis

thus providing a new perspective to further study the early cardiac function

especially the altered diastolic function

in patients with hepatitis B cirrhosis.