肾透明细胞癌Sonazoid与SonoVue超声造影增强特征对照及与增强CT的对比研究

黄浩; 张少飞; 梁华; 土继政; 张凯; 王博娟; 郝磊; 王兴华

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肾透明细胞癌Sonazoid与SonoVue超声造影增强特征对照及与增强CT的对比研究

临床研究 | 更新时间：2024-03-02

- 肾透明细胞癌Sonazoid与SonoVue超声造影增强特征对照及与增强CT的对比研究
- Contrast-enhanced ultrasound enhancement features of clear cell renal cell carcinoma using Sonazoid or SonoVue as ultrasound contrast agents and comparative study with contrast-enhanced CT
- 临床超声医学杂志 2023年25卷第11期
- 作者机构：
  
  1. 山西医科大学医学影像学院
  2. 山西医科大学第二医院
- 作者简介：
- 基金信息：
  
  山西省科技厅重点研发计划项目(编号:201703D421029)
- DOI：
  中图分类号：
- 纸质出版日期：2023，
  
  网络出版日期：2023-12-1，
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黄浩, 张少飞, 梁华, 等. 肾透明细胞癌Sonazoid与SonoVue超声造影增强特征对照及与增强CT的对比研究[J]. 临床超声医学杂志, 2023,25(11).

Contrast-enhanced ultrasound enhancement features of clear cell renal cell carcinoma using Sonazoid or SonoVue as ultrasound contrast agents and comparative study with contrast-enhanced CT[J]. Journal of Clinical Ultrasound in Medicine, 2023,25(11).
黄浩, 张少飞, 梁华, 等. 肾透明细胞癌Sonazoid与SonoVue超声造影增强特征对照及与增强CT的对比研究[J]. 临床超声医学杂志, 2023,25(11). DOI：

Contrast-enhanced ultrasound enhancement features of clear cell renal cell carcinoma using Sonazoid or SonoVue as ultrasound contrast agents and comparative study with contrast-enhanced CT[J]. Journal of Clinical Ultrasound in Medicine, 2023,25(11). DOI：

摘要

[摘要] 目的：对比研究肾透明细胞癌示卓安（Sonazoid）及声诺维（SonoVue）CEUS（Contrast-enhanced ultrasound，CEUS）增强特征，并与CECT（Contrast-enhanced computed tomography，CECT）比较，探讨不同超声造影剂及检查方法在肾透明细胞癌诊断中的应用价值。方法：选取2020年6月至 2023年2月于我院就诊并经病理学确诊的47例肾透明细胞癌患者（共47个病灶）作为研究对象，患者均行CEUS和CECT检查，依据选用超声造影剂类型不同，将患者分为SonoVue组21例，Sonazoid组26例。观察2组患者病灶增强特征，并与CECT对比。结果：1. Sonazoid-CEUS与SonoVue-CEUS相比，两组在肾透明细胞癌病灶增强方式、峰值增强程度及达峰时增强均匀性方面比较差异无统计学意义（P＞0.05）。2. CEUS和CECT增强特征比较：47例肾透明细胞癌病灶CEUS和CECT峰值强度多以富血供表现为主，分别为（42/47，89.36%）和（40/47，85.11%），差异无统计学意义（P＞0.05）；CEUS中病灶达峰时呈均匀弥漫性增强的比例显著高于CECT，分别为（12/47，25.53%）和（4/47，8.51%），二者比较差异有统计学意义（P＜0.05）；CEUS显示病灶增强方式主要表现为快进35例（35/47）、快退42例（42/47），与CECT结果比较，二者差异无统计学意义（P＞0.05）。结论：Sonazoid同样适用于肾脏超声造影，与SonoVue-CEUS及CECT均可用较好的显示肾透明细胞癌的血流灌注特征，不同检查方法相互补充，可为肾透明细胞癌诊断的提供更多有价值信息

Abstract

[Abstract] Objective：To compare the enhancement features of Sonazoid and SonoVue CEUS (contrast-enhanced ultrasound

CEUS) in renal clear cell carcinoma

and compare them with CECT (contrast-enhanced computed tomography

CECT)

to explore the application value of different ultrasound contrast agents and examination methods in the diagnosis of renal clear cell carcinoma. Methods: 47 patients with renal clear cell carcinoma (47 lesions in total) who were diagnosed pathologically in our hospital from June 2020 to September 2022 were selected as the study subjects. All patients underwent CEUS and CECT examinations. According to the different types of ultrasound contrast agents selected

the patients were divided into SonoVue group (21 cases) and Sonazoid group (26 cases). Observe the enhancement characteristics of the lesions in the two groups and compare them with CECT.Results:1. Sonazoid-CEUS and SonoVue-CEUS showed no significant difference in the enhancement mode

peak intensity

and enhancement uniformity of renal clear cell carcinoma between the two groups (P>0.05).2. Comparison of CEUS and CECT enhancement features: The peak intensity of CEUS and CECT in 47 cases of renal clear cell carcinoma was mainly rich in blood supply

which was (42/47

89.36%) and (40/47

85.11%)

respectively

with no significant difference (P>0.05); In CEUS

the proportion of homogeneous diffuse enhancement at the peak of the lesions was significantly higher than that in CECT

which was (12/47

25.53%) and (4/47

8.51%) respectively

and the difference was statistically significant (P<0.05); CEUS showed that the enhancement mode of focus was fast forward in 35 cases (35/47) and fast backward in 42 cases (42/47). Compared with the results of CECT

there was no significant difference between the two (P>0.05). Conclusion; Sonazoid is equally suitable for contrast-enhanced ultrasound of kidney. Like SonoVue-CEUS and CECT

it can well reflect the blood perfusion characteristics of renal clear cell carcinoma

and they can complement each other to provide more valuable information for the diagnosis of renal clear cell carcinoma.

关键词

SonazoidSonoVue超声检查造影剂肾肿瘤X线计算机血管造影术

Keywords

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