r-谷氨酰转肽酶与5’-核苷酸磷酸二酯酶两种同功酶检查对原发性肝癌诊断价值的探讨

周友梅; 沈鼎明; 刘运俊; 徐葆元

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r-谷氨酰转肽酶与5’-核苷酸磷酸二酯酶两种同功酶检查对原发性肝癌诊断价值的探讨

更新时间：2024-01-17

- r-谷氨酰转肽酶与5’-核苷酸磷酸二酯酶两种同功酶检查对原发性肝癌诊断价值的探讨
- THE SIGNIFICANCE OF γ-GLUTAMYL TRANSPEPTIDASE (γ-GTP) AND 5’-NUCLEOTIDE PHOSPHODIESTERASE(5’-NPDase) IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA
- 重庆医科大学学报 1985年第2期页码：97-102
- 作者机构：
  
  重庆医学院第二医院内科教研室
- 作者简介：
- 基金信息：
- DOI：
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- 纸质出版日期：1985，
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[1]周友梅,沈鼎明,刘运俊,徐葆元.r-谷氨酰转肽酶与5'-核苷酸磷酸二酯酶两种同功酶检查对原发性肝癌诊断价值的探讨[J].重庆医学院学报,1985(02):97-102.

THE SIGNIFICANCE OF γ-GLUTAMYL TRANSPEPTIDASE (γ-GTP) AND 5’-NUCLEOTIDE PHOSPHODIESTERASE(5’-NPDase) IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA[J]. Journal of Chongqing Medical University, 1985,(2):97-102.
[1]周友梅,沈鼎明,刘运俊,徐葆元.r-谷氨酰转肽酶与5'-核苷酸磷酸二酯酶两种同功酶检查对原发性肝癌诊断价值的探讨[J].重庆医学院学报,1985(02):97-102. DOI：

THE SIGNIFICANCE OF γ-GLUTAMYL TRANSPEPTIDASE (γ-GTP) AND 5’-NUCLEOTIDE PHOSPHODIESTERASE(5’-NPDase) IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA[J]. Journal of Chongqing Medical University, 1985,(2):97-102. DOI：

摘要

本文对各种肝脏疾病210例

包括原发性肝癌100例

转移性肝癌10例

肝硬化47例

慢性肝炎29例

急性肝炎10例和阻塞性黄疸14例

分别进行r-谷氨酰转肽酶（γ-GT）、5’-核苷磷酸二酯酶（5’-NPDase）同功酶测定。 γ-GT同功酶Ⅰ’、Ⅱ、Ⅱ’带主要是见于原发性肝癌组

100例中67例有Ⅰ’、Ⅱ、Ⅱ’带

占67%;有Ⅰ’带者7例

占7%;有Ⅱ’带者5例

占5%;在肝硬化组中有Ⅱ带者2例

占4%（2/47）;一例郁胆性肝炎出现Ⅰ’带

占3%（1/29）。 38例原发性肝癌中28例出现5’-NPDase同功酶Ⅴ带。占73.6%;转移性肝癌6例中4例有Ⅴ带

占66%;肝硬化中有2例出现Ⅴ带

占10%（2/20）。原发性肝癌AFP阴性和低滴度阳性者11例。其中出现γ-GT-Ⅱ带者7例

占63%

出现5’-NPDase-Ⅴ带者9例

占81％。若将r-GTⅡ带和5’-NPDase-Ⅴ带互相补充

可提高阳性率100%。

Abstract

Y-Glutamyl transpeptidase (Y-GTP) and 5’-Nucleotide phosphodiesterase (5’-NPDase) isoenzymes were studied in 210 cases of various liver diseases

including 100 cases of hepatocellu-lar carcinoma

10 metastatic liver carcinoma

47 liver cirrhosis

29 chronic hepatitis

10 acute hepatitis and 14 obstructive jaundice.Y-GTP isoenzyme I’

II’ were found in.7%

67% and 5% of hepatocellular carcinoma respectively

Y-GTP I could also be found in 2/47 (4%) cases of cirrhosis

and Y-GTP I ’ in a case of chronic hepatitis.5’NPDase V was found

in 28/38 (73.6%) cases of hepaiocellular carcinoma

in 4 out of 6 cases in metastatic liver carcinoma and in 2 out of 10 cases in cirrhosis

Combination of Y-GTP and 5’NPDase isoenzyme positive in 38 cases of hepatocellular carcinoma could raise the positive rate to 97%

and similarly from 63% and 81% to 100% in H cases of hepatocellular carcinoma with normal or low titer of serum AFP.

关键词

γ-谷氨酰转肽酶5-核苷酸磷酸二酯酶

Keywords

γ-Glutamyl transpeptidase5’-Nucleotide phosphodiesterase

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