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重庆医学院第一医院放射治疗室
纸质出版日期:1984,
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[1]王静波,孙世良,何方志,雷自重.鼻腔癌的放射治疗[J].重庆医学院学报,1984(04):269-273.
Department of Radiotherapy Wang Jing-bo. RADIOTHERAPY OF CARCINOMA OF THE NASAL CAVITY[J]. Journal of Chongqing Medical University, 1984,(4):269-273.
<正> 原发性鼻腔癌的发病率较低
文献中单独报导者较少
现将我院自1965~1977年经放射治疗的62例鼻腔癌的远期疗效进行分析和总结
全组中除1例为三年后失访按死亡计以外
余皆经5~17年随访
五年随访率为98.4%。病例资料和治疗方法62例中经临床和 X 线检查
确定局限性
From 1965 to 1977
62 patients of carcinoma of the nasal cavities were treated by radiation the- rapy.Our series comprised 33 cases of anaplastic carcinoma;25 cases of squamous cell carcino- ma;3 cases of adenocarcinoma and 1 case of unclassified carcinoma. The clinical staging of our 62 cases
according to Lederman’s TNM Staging
was as follows: T
1.2
N
0
M
0
14 cases;T
3a
b
N
0
M
0
34 cases
&
T
3a
b
N
1
2
3
M
0
14 cases. In our series
52 cases were treated by external irradiation alone;1 cases was treated by external irradiation complemented with intracavitary radium therapy;three cases were given pre- operative irradiation in combination with surgery;and 6 cases were treated by post-operative irradiation. The dosages of the external irradiation were mostly around TDF 82-109 (50-65 Gy/5-6(1/2) weeks)
only 5 cases of squamous cell carcinoma exceeded TDF 120.For N
1
2
3
stage cases
the metastatic cervical lymph nodes were administered the dosages of TDF 65-82 to 12 cases and TDF 107 to 2 cases.No prophylactic irradiation was givan to No cases. The absolute 5-year survival rate of our 62 cases after treatment was 54.8%(34/62).The 5- year survival rate for those 53 cases treated by radiothreapy alone was54.7%(29/53)
i.e.48.5 % for anaplastic carcinoma
63.2% for squamous cell carcinoma.The 5-year survival rate for our No cases was 64.6%(31/48)
but for N
1
2
3
cases only 21.4%(3/14). 21 of our 62 cases (33.90%)had local recurrence after treatment
6 recurrent cases were tre- ated again by external irradiation alone or by the combination of preoperative irradiation with surgery.4 of thcse 6 cases survived more than 5 years again after the retreatment
we prefer that those recurrent cases should be retreated. In our series
the incidence of severe late sequalae was high
among 62 cases we had 5 cases of radiation necrosis of bone
mainly due to overdosed irradiation. According to our favourable long term treatment results
we also prefer the radiation thera- py should be the method of choice for the treatment of carcinoma of the nasal cavity.The Opt- imal tumor dose for anaplastic carcinoma would be TDF 82-100
and for squamous cell carcinoma would be TDF 90-110.
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