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1. 重庆医学院儿科医院内科
2. 重庆医学院病理解剖教研室
3. 重庆医学院电子显微镜室
4. 重庆医学院第一医院内科
纸质出版日期:1985,
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[1]张恒言,沈锦,刁友芳,章高炎,李维信,唐宜,蔡定栋.过敏性紫癜肾炎180例临床分析与研究[J].重庆医学院学报,1985(03):186-191+233-234.
ANAPHYLACTOID PURPURA NEPHRITIS ANALYSIS OF 180 CASES AND FOLLOW-UP STUDIES[J]. Journal of Chongqing Medical University, 1985,(3):186-191.
本文对儿科医院1956年9月至1983年8月住院的过敏性紫癜肾炎(APN)180例作了临床分析
其临床表现为血尿和/或蛋白尿者占51.1%、肾炎综合征者占43.3%、肾病综合征伴血尿者占5.6%。肾损害与肾外症状无明显关系
用激素治疗与否对近期结局无明显影响
近期临床痊愈40.6%、好转42.2%、无变化16.1%、死亡1.1%。 76例随访11月至26年(平均9年)
体检无异常发现。在资料完整的50例中痊愈30%、尿异常24%、尿异常伴轻度氮质血症46%。作肾活检7例
其血清C
3
均正常
经光镜、电镜、免疫荧光检查2例呈膜增殖肾炎、5例呈系膜增殖肾炎
未见新月体形成
有IgA沉积者5/6例。本组APN的预后较其它文献报告佳。
180 cases of anaphylactoid purpura nephritis with various clinical patterns wer analysed. 51.1% of the cases showed proteinuria and/or hematuria only
43.3% manifested as nephritic syndrome
and 5.6% as nephrotic syndrome with hematuria. There were no clinical correlations between the renal and extrarenal symptoms. The outcome of patients with steroid therapy was not significantly different from those without steroid treatment. 40.6% of the patients were cured
42.2% improved
16.1% unchanged and 1.1% died at discharge from the hospital.76 cases were followed up for 11 months to 26 years (mean 9 years). All of them were physically normal. Detail studies had been carried out in 50 cases. 30% were cured. 24% still showed some abnormal urine findings and 46% showed abnormal urine with mild azotemia. Renal biopsy was done in 7 cases with abnormal findings. Biopsy samples were examimed with light microscopy
electron microscopy and im-munoflorescence. 5 cases were diagnosed .as mesangial proliferative glomerulonephritis
and the other 2 as membrano-proliferative glomerulonephritis. No crescent formation was found. IgA deposits in the glomeruli were seen in 5 of the 6 cases examimed. Tne outcome of this series was better than other reports.
肾炎过敏性紫癜过敏性紫癜肾炎系膜增殖肾炎膜增殖肾炎肾活检
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