The direct method to obtain chromosome metaphase from human chorionic villi is a new method of early prenatal diagnosis. Our modified method for preparing the chromosome obtained a satisfactory result. It indicated that the cases of metaphase appearance were 100%

and the cases of fetal karyotype were 94%. This method used in 6th to llth week of preganacy

especially 7th week were suitable and it is more reliable to compare with the method of chorionic villi cell culture

since the possibility of contamination of maternal cell is so amall. T his method is easy

fast

effective and easy to control to be populated for early prenatal diagnosis .