In order to find out the effect of body fluid and variation of peripheral blood picture under two different output of nitrogen laser irradiation.So as to provide scientific basis for clinical application of nitrogen laser and to conjecture probable harm in body. The low output nitrogen laser is 0.2mj

the high output nitrogen laser is 3mj.The rabbits are put in the metabolic cages and collect 24 hrs urine for VMA examination;Cholinesterase from the whole blood and routine test of blood smear were examined.There are of two days interval between the two irradiation.They were examined before and after irradiation and both result used by pair comparison. The low output laser after 3rd irradiation the rabbits VMA in urine was decreasad.The high output laser lst irradiation the VMA in urine was decreased at once.But both of two different ou- tput laser irradiation were no statistical significace on the Cholinesterase and number of neutro phils.Two different output nitrogen laser irradiation on erythrocytes

hematoglobulin synthesis have been stimulated

but no significant variations on the platelets.