Artificial Liver Research Laboratory Shu Changda Li Zongming. THE REMOVAL OF MIDDLE MOLECULES IN SERUM OF UREMIC RATS BY CHARCOAL HEMOPERFUSION[J]. Journal of Chongqing Medical University, 1984,(4):253-256.
Artificial Liver Research Laboratory Shu Changda Li Zongming. THE REMOVAL OF MIDDLE MOLECULES IN SERUM OF UREMIC RATS BY CHARCOAL HEMOPERFUSION[J]. Journal of Chongqing Medical University, 1984,(4):253-256.DOI:
It was proposed that middle mollecular weight compound (350-5000 daltons)may present :part of the toxic molecules responsible for uremic patients.In bilateral nephrectomy rat model
the serum middle molecules increased markedly.Agarose encapsulated charcoal (CAAC Ⅱ)as we- 11 as albumin collodion coated active charcoal (ACAC) and uncoated charcoal were used as adso- rbents during hemoperfusion.All kinds of charcoal can adsorb middle molecules both in vitro and in vivo.The CAAC Ⅱ can adsorb more middle molecules than the uncoated one
becuase the larger molecules cannot pass the encapsulated membrane of the former and spared more spa- ce for adsorbing MM.