n this study

the reverse- pliase HPLC was used to determine the serum and urine concen- tration of ciprofloxacin in 6 healthy volunteers during and after a 60-minute intravenous infu-sion of 200mg of its lactate. The compartnient model was determined by F value

r￣2 and AIC.Theserum drug concentration-time profile conformed to the two-compartment open model. Afterintravenous infusion

the peak level was 3.84 ± 0.35ug/ml.The elimination half-life

the apparentvolume of distribution and the area under the serum concentration curve were 3. 28h

1. 54L/kgand 10. 12mg.h/L

respectively. After a 60-minute intravenous infusion of 200mg ciprofloxacin lactate

the urinary recoveryrate winthin 24h was 78.94% of administered dose and this indicates that this drug is eliminatedmainly from the kidney