5 cases of mammary paget s discase have been studied with immunohistochemical technique. The antibodies used were directed against cytokeratin and epithelial membrane antigen. The paget’scells of all cases expressed cytokeratin and epithelial mem brane antigen

Cellular phenotype wasconsistent with the underlying intraduct or invasive carcinoma.The results of observation demon-strate that the paget’s cells derive from tht underlying breast carcinoma

but the possibility of somecases originating from epidermis cannot be excluded.