糖尿病红细胞膜Na＋－K＋—ATP酶和Mg2＋—ATP酶活性改变与脂

邓华聪; 邱鸿鑫; 汪恕萍; 粟绍初; 李萍

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糖尿病红细胞膜Na^＋－K^＋—ATP酶和Mg^2＋—ATP酶活性改变与脂

更新时间：2024-01-17

- 糖尿病红细胞膜Na^＋－K^＋—ATP酶和Mg^2＋—ATP酶活性改变与脂
- THE RELATION BETWEEN CHANGES OF Na+-K+-ATPase ACTIVITY AND Mg2+- ATPase ACTIVITY AND LIPID PEROXIDATION OF ERYTHROCYTE MEMBRANE IN NIDDM PATIENTS
- 重庆医科大学学报 1996年第2期
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  中图分类号： R587.1
- 纸质出版日期：1996，
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[1]邓华聪,邱鸿鑫,汪恕萍,粟绍初,李萍.糖尿病红细胞膜Na~＋－K~＋—ATP酶和Mg~（2＋）—ATP酶活性改变与脂[J].重庆医科大学学报,1996(02):111-114.

Deng Huacong, et al. THE RELATION BETWEEN CHANGES OF Na+-K+-ATPase ACTIVITY AND Mg2+- ATPase ACTIVITY AND LIPID PEROXIDATION OF ERYTHROCYTE MEMBRANE IN NIDDM PATIENTS[J]. Journal of Chongqing Medical University, 1996,(2).
[1]邓华聪,邱鸿鑫,汪恕萍,粟绍初,李萍.糖尿病红细胞膜Na~＋－K~＋—ATP酶和Mg~（2＋）—ATP酶活性改变与脂[J].重庆医科大学学报,1996(02):111-114. DOI：

Deng Huacong, et al. THE RELATION BETWEEN CHANGES OF Na+-K+-ATPase ACTIVITY AND Mg2+- ATPase ACTIVITY AND LIPID PEROXIDATION OF ERYTHROCYTE MEMBRANE IN NIDDM PATIENTS[J]. Journal of Chongqing Medical University, 1996,(2). DOI：

摘要

本文探讨了ＮＩＤＤＭ患者红细胞膜Ｎａ￣＋—Ｋ￣＋—ＡＴＰ酶及Ｍｇ￣（２＋）—ＡＴＰ酶活性改变与脂质过氧化的关系，以及这两者在糖尿病微血管并发症发生中所起的作用。结查显示，ＮＩＤＤＭ患者红细胞膜Ｎａ￣＋—Ｋ￣＋—ＡＴＰ酶与Ｍｇ￣（２＋）—ＡＴＰ酶活性显著降低。而红细胞膜ＬＰＯ则显著增高。红细胞ＳＯＤ及ＧＳＨｐｘ活性显著降低，伴有糖尿病视网膜病变者以上变化更为显著。红细胞膜Ｎａ￣＋—Ｋ￣＋—ＡＴＰ酶和Ｍｇ￣（２＋）—ＡＴＰ酶活性与红细胞膜ＬＰＯ、红细胞ＩＦ呈显著负相关，红细胞膜ＬＰＯ与红细胞ＩＦ呈显著正相关，表明红细胞膜脂质过化增强是导致膜Ｎａ￣＋—Ｋ￣＋—ＡＴＰ酶和Ｍｇ￣（２＋）—ＡＴＰ酶活性降低的重要因素，并且它们都参与糖尿病视网膜病变的发生。

Abstract

he activities of Na+-K+-ATPase and Mg2+-ATPase and lipid peroxidation of erythrocytemembrane in 40 non-insulin-dependant diabetes mellitus(NIDDM) patients were inves-tigated

The results showed that the activities of Na+-K+-ATPase and Mg2+-ATPase oferythrocyte membrane were significantly decreased in diabetics while the level of lipidperoxide(LPO)of erythrocyte membrane was significantly increased.Sunultaneously

the activities ofsuperoxide di smutase and glutathine peroxidase of erythrocrte were significantly lowered indiabetics as compared with normal controls.The above abnormal changes were more markwt indiabetics with retinopatliy than in those without retinopathy. The changes of the activity of Na+-K+-ATPase and Mg2+-ATPase were inversely correlated with errythrocyte membraneLPO and index of errythrocyte filtrati on (IF).These suggested that the signi ficant enhancement oflipid peroxidation of erythrocyte membrane may be respousible for the decrease of the activify ofNa+-K+-ATPase and Mg2+-ATPase which may be involved in the pathogenesis of diabcticretinopathy.

关键词

NIDDM红细胞膜Na￣＋—K￣＋—ATP酶Mg￣（2＋）—ATP酶脂质过氧化

Keywords

NIDDMErythrocyte membraneNa+-K+-ATPaseMg2+-ATPaseLipid per- oxidation

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