olumns of gel pellets which were made of 3 % sodium alginate and 2.2% calcium cliloride werevery resistant to compression and abrasion during passage of high concentration of sucrose at highflow rates.No leakage of cells occurrde during agitation for long periods. So this new calciumalginate pellets appear to have excellent physieal characteristics for use as an islets immobilizationsupport in the treatment of diabetes mellitus.