he early changes of cardiac function were studied in alloxan dialbetic rabbits in comparison with nomlal con-trols.After the onset of dialsetes for 4 weeks

left ventricular function indices including the peak pressure of leftventricule(Peak)

the end diastolic pressure(EDP)the isovolumic contraction pressure(IP)

the Peak negative -dp/dt max

(-Smax)and the area of lieart Working cycle(Area)were all significantly lower then those of normalcontirols(IP

-Smax

P < 0.005);Area(P< 0.05)EDP

P(<0.001)The results suggested that eraly decrease of leftventricular contraction and relaxation mdy be relaed to abnomal metabolism and diabetic cardiomyopathy.