n this study we measured the ablity of doxepin adhesive patch(DAP)to antagonize allergicreactions

Three doses of DAP containing 0. 2% and 0. 5% of doxepin respctively decreased sig-nificantly the mouse ear weights related to the cutaneous allergic reaction induced by 2

4-dini-trochlorobezene

the ear weights of treated groups were 11

4± 1.3 and 11.6± 1.2mg respeetively

and the weight of control group was 15.9±2. 2m(all P <0. 01);DAP also reduced vasodilationareas provoked by histamine on the bake of the rats.the areas in treated groups were 0.04 ±0.06and 0. 40 ± 0. 54cm

and the control

group was 1. 42 ± 0. 71cm(all P <0. 01). Two doses of DAPcontaining 0

2% and 0.05 % of doxepin respectively increased the amounts of histamine to pro-voke itching response on the skin of guinea pigs by 635 5 ± 99 and 158 ± 43ug

as compared with30 ± 29.4ug of control groug (all P<0.01);and decreased the infiammatory capillary permeabilityby 0. 17±0.05 and 0.20±0. 13(A value)in treated mouse

control mice:0.39±0.06(all P<0.01)。These experiments demonstrate that DAP is a potent anti-allergic prepration。