斯巴沙星对革兰氏阳性菌体外抗菌活性研究

肖永红; 王其南; 李崇智; 陈海; 刘鸿渝

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斯巴沙星对革兰氏阳性菌体外抗菌活性研究

更新时间：2024-01-17

- 斯巴沙星对革兰氏阳性菌体外抗菌活性研究
- IN VITRO ANTIMICROBLAL ACTIVITY OF SPARF-LOXACIN AGAINST GRAM POSITIVE BACTERIA
- 重庆医科大学学报 1996年第3期
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  中图分类号： R978.19
- 纸质出版日期：1996，
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[1]肖永红,王其南,李崇智,陈海,刘鸿渝.斯巴沙星对革兰氏阳性菌体外抗菌活性研究[J].重庆医科大学学报,1996(03):212-214.

IN VITRO ANTIMICROBLAL ACTIVITY OF SPARF-LOXACIN AGAINST GRAM POSITIVE BACTERIA[J]. Journal of Chongqing Medical University, 1996,(3).
[1]肖永红,王其南,李崇智,陈海,刘鸿渝.斯巴沙星对革兰氏阳性菌体外抗菌活性研究[J].重庆医科大学学报,1996(03):212-214. DOI：

IN VITRO ANTIMICROBLAL ACTIVITY OF SPARF-LOXACIN AGAINST GRAM POSITIVE BACTERIA[J]. Journal of Chongqing Medical University, 1996,(3). DOI：

摘要

测定斯巴沙星对１３６株革兰氏阳性菌抗菌活性，并与其它４种抗菌药物比较。结果表明斯巴沙星对葡萄球茵、肠球菌、肺炎球菌、草绿色及溶血性链球菌的ＭＩＣ９０为０．０６－８μｇ／ｍｌ，远较苯唑西标及头孢唑啉低，其抗菌活性为氧氟沙星的２—１６倍，环丙沙星的１—８倍。对甲氧西林敏感与耐药的葡萄球菌，氟喹诺酮类具有相同抗菌活性，ＭＩＣ９０均为２—１６μｇ／ｍｌ。斯巴沙星为临床治疗革兰氏阳菌感染的有效药物。

Abstract

he in vitro antunicrobial activity of sparfloxacin against 136 Gram positive bacterial strainwas tested and compared with those of 4 other antimicrobial agents.The results showed that theMIC90s of sparfloxacin against staphylococcus

enterococcus

Stroptoco ccus pneumoniae and otherstreptococcus species were 0.06-8ug/ml

which were much lower than tho se of oxacillin andcefazolin.Sparfloxacin was 2-16 and 1-8 times more potent than ofloxacin and ciprofloxacinrespectively.Fluoroquinolones had the same activity against methicillin sensitlve and resistantstaphylococcus.Sparfloxacin would be an effective agent in the troatment of infections caused byGram positive bacteria.

关键词

革兰氏阳性菌斯巴沙星体外抗菌活性

Keywords

SparfloxacinGram positive bacteriaIn vitre antimicrobi al activity

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