n improved High Performance Liquid Chromatographic Method for determination of vita-mine c in serum was used. The pharmacokinetics of high-dose vitamine c was studied in 9adults after intravenous injection of a dose of 10g。 The data were fitted by nonlinear regressionautomatic program and proved to be

ubjected to two compartment open model. The serum con-centration-time equation vyas Ct=680. 0224￣(0.646t)+28. 7868￣(0.044t). The pharmacokiontic parameterswere:t1/2a=1.1±0.17hr

t2/2β=17.67±6.3hr

Vc=14.48±2.31

V2=131. 43±421.The clinical im-plications of results are discussed。