he levels of insulin secretion from isolated rat pancreatic islets maintained in culture for 5 daysin the presence of 1.54 or 15.4Vμmol/L T3 concentration were measured. Comparing with the controlislets

both acute and chronic phases of glucose-induced insulin release from the islets treated with T3(1.54umol/L)were significantly decreased at 11.1 or 22. 2mmol /L glucose concentration in the cul-ture medium. It suggested that T3 had a delay affect on the inhibition of glucose-induced insulin se-cretion from the isolated pancreatic islets under condition of a high extracellular concentration of glu-cose

and the change of insulin content in the islets may contribute to the alterations of glucose-in-duced insulin secretion in the presence of T3