The levels of Glutathione S-transferase Pi(GST-π)isoenzyme were measured by ABC-immunohistoche-mical methods in human lung tissue from 30 patients with lung cancer(LC)

30 patients with benign pulmonarydiseases(BPD)and normal controls(NC)Results:the positive staining rate of GST-πin patients with LC was66.7%

amony which

the positive rate with sgyamous(AC)were 87.5% and 66.7% respectively All cases withlarge cell carcinomas (SCC)and adenocarcinomas cell carcinoma (LCC)and small cell lung cancer(SCLC)werenegative staining

3 of 30 the cases (10%)in side-tumor lung tissue were shown weak positive staining.no caseswere found positive staining the lung tissue of normal and BPD groups However

the intensity of GST-π stainingappeared to be dpendent on the differentiation grade of AC

The well-differentiated of AC expressed highGST-π.Conclusions:the levels of GST-π may be available marker for NSCLC

especially adenocarcinomas andSguamous cell carcinoma.