Seventy -seven patients with endoscopically proven duodenal ulcer (DU) with positive Helicobacter pylori (Hp) infection were divided into two groups. Group A (32) was given a low dose triple therapy and Group B (45)

a standard dose triple therapy for two weeks. The results showed that the eradication rate of Hp of group A was 76.9% (20/26) and group B

85 7%(30/35);the cure rate of DU of group A was 92 3%(24/26)

and group B

94 3%(33/35). Both of the eradication rate of Hp and the cure rate of DU were of no significant differences statistically (p=ns).But the side effects of drugs appeared in 3 of 32 (9 3%) in group A

and in 20 of 45(44 4%) in group B. There was a significant difference statisticalluy between two groups. After a period of 6 month follow up

the total relapse rate of DU was 17%(4/23) in group A

and 3% (1/33) in group B.