The effects of tramadol on mouse emotinal respones and electricity provoked guinea pig pharyngeal reflex were studied.80 mice and 40 guinea pigs were divided into 4 groups.Scopolamine

scopolamine combined with tramadol

atropine or atropine combined with tramadol were injected before surface anesthesia respectively.The results showed that tramadol had increased the number of electric stimulus for enraging mice and raising the voltage threshold of guinea pig pharyngeal reflex(P<0.01).Tramadol enhanced the central sedation effect of scopolamine and reduced central excitation effect of atropine. In clinical practice

160 patients with vocal cord polyp operation were divided into 4 groups and were medicated as above.It was found that when tramadol was used as a supplementary mediction in surface anesthesia

it could reduced the dosage of tetracaine

shorten time of operation and alleviate patient’s pain or discomfort.