Using the spectrum absorption

we have deternined the contents of the copper

manganese

zinc andiron in the alloxan-induced diabetic rat diaphragm muscles

ad detected their activities of superoxide dismutase (SOD) and contents of malondiadehyde(MDA). The results indicated that the copper and zinc were lower and the iron was higher in diabetic rat diaphragm muscles than in control group

but in manganese

there were no significant defferences between control and diabetic group

The activites of SOD decreased significantly and the contents of MDA increased significantly in diaphragm of diabetic rats as compared with the control group

In diaphragm of the diabetic rats. The results suggest that the changes of the contents of Cu

Zn

Fe and the increases of oxidative stress in diaphragm may be related to the early diabetes

The zinc plays an importment role in lipid Peroxidation of diabetic diaphragm.