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纸质出版日期：1997，
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[1]何畏,叶之美,卞度宏.卵巢癌患者全身及肿瘤局部细胞免疫功能的测定[J].重庆医科大学学报,1997(01):36-38.
The study on body’s and local cellular immune activity in ovarian carcinonma[J]. Journal of Chongqing Medical University, 1997,(1).
[1]何畏,叶之美,卞度宏.卵巢癌患者全身及肿瘤局部细胞免疫功能的测定[J].重庆医科大学学报,1997(01):36-38. DOI：
The study on body’s and local cellular immune activity in ovarian carcinonma[J]. Journal of Chongqing Medical University, 1997,(1). DOI：
本文运用噻唑蓝比色法。间接免疫荧光法测定了３１引例晚期卵巢癌患者的外周血淋巴细胞（ＰＢＬ）、腹水淋巴细胞（ＥＡＬ）及肿瘤浸润淋巴细胞（ＴＩＬ）的ＮＫ活性和细胞亚群，并对常规手术、化疗对肿瘤患者免疫功能的影响进行初步探讨。结果：卵巢癌患者的ＰＢＬＮＫ活性明显低于正常和良性钟瘤组，其中ＣＤ＋３、ＣＤ＋４及Ｂ细胞较少，ＣＤ＋４／ＣＤ８＋比值较低；而ＴＩＬ的ＮＫ活性较ＰＢＬ更为低下，其ＣＤ＋４／ＣＤ＋８严重失衡。推测：卵巢癌患者机体免疫功能全面受抑，尤以局部明显；传统手术、化疗同辅以增强免疫的支持治疗有望改善患者预后。
The nature killer (NK)activity and the subset of lymphocytes isolated from peripheral blood(PBL)
ascitic fluid (EAL)and fresh tumor tissue(TIL)were studied on 31 cases of advanced ovarian carcinoma(AOC)
using MTT
ID-IF methods.The AOC showed lower NK activity
fewer CD + 3、CD + 4/CD + 8+ration in PBL
compared with normal women and women with benign tumor.Both TIL and EAL contained much fewer CD + 3
CD + 4 and B lymphocytes than PBL.The NK activity of TIL was significently decreeased.The CD + 3
CD + 4 and B ymphocytes decreased after chemtherapy too.These suggest that the immunocompetence is impaired in AOC
especially in the tumor-surrounding area
It can be further suppressed by chemotherapy.So immunotherapy should be combined with operation and chemotherapy in the treatment of AOC.
卵巢肿瘤免疫学
Ovarian CarcinomaImmune Activit
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