Abstract Forty - four cases of endometrial cancer and ten cases of serious endometrial atypical hyperpalsia were studied for expression of p53
C - erbB - 2 and ER with immunohistochemical method. The positive rates of p53
C -erbB - 2 and ER in endometrial cancer were 47.7%
95.5% and 88.6%
and in serious endometrial atypical hyperplasia wcrc 0%
10%and 100%. The results showod that the C - erbB - 2 is one of sueful indicators of the differential diagnosis between endometrial cancer and serioue endometrial atypical hyperpalsia.The combination of p53
C - erbB - 2 and ER will have important clinical value on the evaluation of prognosia and the treatment of endometrial cancer.