氨基胍对糖尿病大鼠任意尿Pr/Cr比值和感染率的影响

戎健; 邱鸿鑫; 汪恕萍

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氨基胍对糖尿病大鼠任意尿Pr/Cr比值和感染率的影响

更新时间：2024-01-17

- 氨基胍对糖尿病大鼠任意尿Pr/Cr比值和感染率的影响
- Effects of aminoguaniding onthe random urinary Pr/Cr ratio and the rate of infectionin diabetic rats
- 重庆医科大学学报 1997年第2期
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  中图分类号： R587.2
- 纸质出版日期：1997，
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[1]戎健,邱鸿鑫,汪恕萍.氨基胍对糖尿病大鼠任意尿Pr/Cr比值和感染率的影响[J].重庆医科大学学报,1997(02):93-96.

Effects of aminoguaniding onthe random urinary Pr/Cr ratio and the rate of infectionin diabetic rats[J]. Journal of Chongqing Medical University, 1997,(2).
[1]戎健,邱鸿鑫,汪恕萍.氨基胍对糖尿病大鼠任意尿Pr/Cr比值和感染率的影响[J].重庆医科大学学报,1997(02):93-96. DOI：

Effects of aminoguaniding onthe random urinary Pr/Cr ratio and the rate of infectionin diabetic rats[J]. Journal of Chongqing Medical University, 1997,(2). DOI：

摘要

本文对４０只用链脲菌素诱导的糖尿病大鼠进行适当控制，对比观察氨基胍和胰岛素对糖尿病大鼠任意尿蛋白／肌酐（Ｐｒ／Ｃｒ）比值的影响。结果表明与胰岛素相比，氨基胍能明显降低任意尿Ｐｒ／Ｃｒ比值。提示氨基胍对糖尿病的访治有重要意义。同时本文还发现氨基胍能降低糖尿病大鼠感染率，提示氨基胍或晚期糖基化终末产物对糖尿病大鼠免疫功能有影响

Abstract

In 40 streptozotocin - induced diabetic rata

the effect of aminoguanidine on random urinary pro- tein/creatinine (Pr/Cr) ratio was compared with that of insulin. It was found that the Pr/Cr ratio was significantly lower in the diabetic rats treated with aminoguanidine and insulin as compared with those treated with insulin alone

suggesting that aminoguanidine can prevent the development of diabetic nephropathy.At the same time

the rate of infection i. aminoguanidine - treated group was also significantly lowered

suggesting that aminoguanidine or advanced glycosylation end - products can affect the immune function of diabetic rats.

关键词

糖尿尿肾病尿蛋白感染氨基胍

Keywords

Diabetic nephropathyProteinuriainfectionAminoguanidine.

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