atrine

a kind of alkaloids which purified from legume family

such as chinese herbs Sophora flavescencesAit

and Radix sophorae Tinkinensis

has multiple pharmaceutical effects.But the most one attractive toresearchers is that matrine could induce the human leukemia cell line differentiation.In order to elucidate themechanism by which the matrine acts

according to the structural and physi-chemical features of matrine

aswell as the research objection

the matrine was labeled by tritium(H) through the methods of isotope catalyzeexchange labeling.The results:RTA.Meanwhile the H matrinealso identified by PC

HPLC and bio-effect determination.It indicates that the matrine labeled by tritium wassuccessful

and the labeline product can the labeling product can meet the requirements for further study.