o determine the improving effect of GIK Solution on insulin resistance and metabolic disorder in patients receiving valve replacement operations without diabetes during the period of CPB

20 patients were divided into 2 groups. GIK group(n=10) and control group(n=10). insulin

which was contained in GIK(I/G = 1:1)solution was infused continuously at a rate of 1u/kg/h into the patients of GIK group and nothing was done to the patients of control group during the period from induction of anesthesia to clamping aortic flow. 20 blood samples were obtained respectively from patients of two groups at the following intervals:(1) Before anesthesia (2) Before CPB (3)After 15 min CPB (4) 6 min after declamping of aorta (5) 20 min after CPB.Insulin

c - peptide

cortisol

growth hormone as well as blood glucose in samples were measured. The levels of blood glucose. cortisol are significantly reduced and c - peptide

while insulin sensitivity are increased in GIK group. Hormonal. carbohydrate metabolism responses and the secretion of pancreatic beta cells are improved by GIK Solution