Din Fang. et al Chengdu First People’s Hospital. Expression of nm23 - H1、C - erbB2. products in transitional cell carcinoma of uronary bladder[J]. Journal of Chongqing Medical University, 1998,(1).
Din Fang. et al Chengdu First People’s Hospital. Expression of nm23 - H1、C - erbB2. products in transitional cell carcinoma of uronary bladder[J]. Journal of Chongqing Medical University, 1998,(1).DOI：
produces in 61 cases of human bladder transitional cell carcinoma(TCC) was studied. There was decreased expression of nm23-H1 protein as the cancer grade increased.Among three grades and-between superficial and invasive hladder TCC
nm23-H expressed in distinct positive rate.No relation was found between the nm23 - H1
expression and lympb - node metastasis. 23 of 61 cases of bladder TCC were found to be immunohistologically positive with anti-C-erbB2
protein antibody.C-erbB2
gene products were more commonly detected in high - grade invasive tumors. 40 percent of superficial bladder TCC(TA-T1) showed nm23 - H1 proteins positive and C - erbB2 negative
while 47.6 percent of . invasive bladder(T2 - T4) TCC expressed C - erbB2 protein
meanwhile nm23 - H1 was negative.The significance and possible mechanisms of both nm23 - H1 protein and C - erbB2 protein change in human bladder TCC were discussed.
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