- P immunohistochemical method was used to examine the expression of EGFR in 75 cases (5 normal gastric mucosas

20 gastric mucosal dysplasias

50 gastric carcinomas) and 27 paracarcinous tissues. The expression of EGFR was negative in 5 normal gastric mucosas. Statistically

the positive rates of EGFR in moderat and severe dysplasias

advanced gastric carcinomas

paracarcinous abnormal tissues and the group with metastasis were significantly higher than those in slight dysplasias

early gastric carcinomas

paracarcinous normal tissues and the group without metastasis

respectively. The results showed that EGFR positive expression might play an important role in the process of carcinogenesis of gastric mucosa and serve as a molecular marker of gastric premalignant lesions. The detection of E GFR is helpful for prognosis of gastric carcinoma.