肝癌患者血浆肿瘤坏死因子及其可溶性受体I的意义

刘超; 姚榛祥

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肝癌患者血浆肿瘤坏死因子及其可溶性受体I的意义

更新时间：2024-01-17

- 肝癌患者血浆肿瘤坏死因子及其可溶性受体I的意义
- The significance of plasma TNF and its soluble receptor I for patients with primary hepatocellular carcinoma
- 重庆医科大学学报 2001年第1期页码：48-50
- 作者机构：
  
  重庆医科大学临床学院普外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R735.7
- 纸质出版日期：2001，
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[1]刘超,姚榛祥.肝癌患者血浆肿瘤坏死因子及其可溶性受体I的意义[J].重庆医科大学学报,2001(01):48-50.

The significance of plasma TNF and its soluble receptor I for patients with primary hepatocellular carcinoma[J]. Journal of Chongqing Medical University, 2001,(1):48-50.
[1]刘超,姚榛祥.肝癌患者血浆肿瘤坏死因子及其可溶性受体I的意义[J].重庆医科大学学报,2001(01):48-50. DOI：

The significance of plasma TNF and its soluble receptor I for patients with primary hepatocellular carcinoma[J]. Journal of Chongqing Medical University, 2001,(1):48-50. DOI：

摘要

目的：探讨肝癌患者血浆TNF和sTNFR-I的临床意义。方法：分别用放射免疫法和ELISA法检测36例肝癌患者血浆TNF和sTNFR-I 。结果：肝癌患者血浆TNF、sTNFR-I均显著高于肝硬变和正常人，sTNFR-I水平与AFP、TB、g-GT、ALP无关，与血清白蛋白水平呈负相关，III、IV期或门脉癌栓患者sTNFR-I高于 II期或门脉无癌栓患者，TNF与分期及门脉癌栓无关；有效治疗后sTNFR-I水平明显降低。结论：sTNFR-I可能参与了肿瘤细胞的免疫逃避机制，检测sTNFR-I有助于了解肝癌患者的免疫状态、病程分期、判断预后、监测治疗，临床价值优于TNF测定。

Abstract

Objective: To investigate the clinical significance of measurement of sTNFR-I and TNF in patients with primary hepatocellular carcinoma (PHC). Methods: Plasma TNF and sTNFR-I levels were measured in 36 patients with PHC by radioimmunoassay and ELISA respectively. Results: Both plasma levels of TNF and sTNFR-I in PHC were significantly higher than those in liver cirrhosis and healthy controls

which did not correlate with AFP

total bilirubin

g-GT

ALP

but negatively correlated with serum albumin concentration. sTNFR-I in patients with PHC of stage TNM III-IV or with portal embolus were significantly higher than those of stage II or without portal embolus. TNF correlated with neither stage nor portal embolus. sTNFR-I decreased significantly after effective therapy. Conclusion: sTNFR-I possibly involved in the immunological escape mechanism of tumor cells. Plasma sTNFR-I levels in patients with PHC correlated with disease status closely and the determination could be helpful to recognize patients’ immune status and staging of disease

predict prognosis

monitor therapy with a clinical value much better than TNF.

关键词

肝肿瘤肿瘤坏死因子肿瘤坏死因子受体

Keywords

liver neoplasmtumor necrosis factorTumor necrosis factor receptor

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