Objective: To investigate the effect of amniotic membrane transplantation for severe surface disorders. Methods: Simple amniotic membrane transplantation 15 eyes and combined with lamellar keratoplasty 16 eyes were performed on severe ocular surface disorders ( acute ocular chemical and thermal burns 6 eyes

chronic ocular burn with severe symblepharon and other ocular surface disease 25 eyes). These patients were followed for 3-18 months ( mean 8.4 months). Results: The inflammation was decreased obviously in four out of six acute eye burns

no progressive corneal melting and perforation were seen . Ocular surface reconstruction was successful in 20 of 25 eyes with choronic ocular surface disorders. Symblepharon was cured or decreased. Visual acuity was improved in various degrees. Conclusion: Amniotic membrane transplantation can effectively reduce inflammation and block corneal melting in acute eye burn. As a good biologic material amniotic membrane can be used to reconstruct ocular surface for treating chornic ocular burn with symblepharon and other ocular surface diseases.