子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达

令狐华; 徐小蓉; 庄琳; 周晓; 赵建武

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子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达

更新时间：2024-01-17

- 子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达
- Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis
- 重庆医科大学学报 2002年第4期页码：383-385
- 作者机构：
  
  1. 重庆医科大学临床学院妇产科,重庆医科大学临床学院妇产科,四川省妇幼保健院,重庆市第四人民医院,重庆医科大学第二临床学院重庆　400016,重庆　400016,成都,610041
  2. ,重庆,400010
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R711.71
- 纸质出版日期：2002，
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[1]令狐华,徐小蓉,庄琳,周晓,赵建武.子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达[J].重庆医科大学学报,2002(04):383-385.

Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis[J]. Journal of Chongqing Medical University, 2002,(4):383-385.
[1]令狐华,徐小蓉,庄琳,周晓,赵建武.子宫内膜异位症在位及异位子宫内膜Fas、FasL的表达[J].重庆医科大学学报,2002(04):383-385. DOI：

Expression of Fas and Fas ligand in eutopic and ectopic endometrium of women with endometriosis[J]. Journal of Chongqing Medical University, 2002,(4):383-385. DOI：

摘要

目的：检测子宫内膜异位症（EM）患者在位及异位内膜中Fas，FasL蛋白的表达，探讨其在子宫内膜异位症免疫发病机制中的作用。方法：采用免疫组织化学（SP）法分别测定了EM患者在位和异位内膜及正常对照子宫内膜中Fas，FasL蛋白的表达。结果：1、EM患者在位内膜及正常对照子宫内膜中Fas及FasL的表达均呈周期性改变，增生期呈低水平表达，分泌期表达增高，两组间同期别比较增生期无显著差异，分泌期EM患者在位内膜的Fas及FasL表达均低于正常对照组；2、异位子宫内膜中的Fas及FasL的表达都呈现低水平或不表达。结论：子宫内膜异位种植可能与Fas及FasL的表达障碍有关。

Abstract

Objective: To investigate the effect of Fas/ Fas ligand expression on the pathogenesis of endometriosis( EM ). Methods: Immunohistochemistry was used to assess the expression of Fas and Fas ligand (FasL) in ectopic and eutopic endometrium from patients with EM and those from controls. Results: Eutopic endometrium showed a cyclic change in correlation with the menstrual cycle both in patients with EM and in controls

with Fas/FasL staining found to be increased in secretory phase compared with those in proliferative phase. Although no difference was found between patients with EM and control in their Fas/FasL expression in proliferative phase

there was a decreased level of Fas/ FasL expression in secretory endometria of patients with EM . Notably

expression of the two parameters in ectopic endometrium was observed to be quite low. Conclusion:The low level of Fas and FasL expression in secretory eutopic endometrium and in ectopic endometrium may participate in the ectopic transplantation of endometriosis.

关键词

子宫内膜异位子宫内膜FasFas Liand

Keywords

EndometriosisendometriumFasFas ligand

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