Objective: To evaluate the safety

tolerance and effectiveness of the domestic nonionic contrast medium Iohexol in CT contrast enhancement scanning of the head. Methods: CT contrast enhancement scanning was performed on 258 cases

in which 154 cases were male and 104 cases were female ;142 cases had high-risk factors;253 cases were found to have diseases and 5 cases were normal. All cases were examined with the same equipment and scanning methods

and with the same contrast medium and the same dosage. CT values of arteria cerebri media and superior sagittal sinus were measured. Blood pressure

heart rate and adverse reactions were recorded .The standards of evaluation included the enhancement quality

non-transparency

whole body tolerance

local tolerance and side effects. Results: “” The enhancement qualities in all cases were excellent. The pre-and post-contrast CT values of arteria cerebri media and superior sagittal sinus changed significantly (P<0.0005); the “”whole-body and local tolerance were good; side effects were slight and rare. Conclusion: In CT contrast enhancement scanning of the head

Iohexol has a high clinical safety

tolerance and effectiveness

and few side effects. It rarely causes changes in heart and renal function.