Objective: To get the experiment data and experiences for clinical liver transplantation

the anesthesia method and hemodynamic changes were observed during the surgery of pig liver transplantation model. Methods: 24 healthy

young and cross-racial pigs were divided into two groups at random. 12 donators

12 receivers. During balanced-anesthesia

the changes of MAP

CVP

ACT were monitored. VVB was done at anhepatic phase. The hemodynamic changes during 3 phases were monitored. Results: Because of the special anatomy of pigs

the intubation was difficult and requires higher techniques. The oral intubation was successful in 21 cases

and tracheotomy in 3 cases. The hemodynamic changes were remarkable during anhepatic phase and primary neohepatic phase . The blood back flow blockage was successfully prevented by extracorporeal vein-vein bypass

and the stability of circulation was well maintained. Being compared with the pre-anhepatic phase

there were remarkable differences of the dropping of shell temperature and the changing of ACT during anhepatic phase

primary neohepatic phase and neohepatic phase. Conclusion: Using EVVB during the anhepatic phase can be helpful to maintain hemodynamics and blood biochemistry stable. It is an important experience for clinical liver transplantation.