Objective: To study the correlated risk factors about diabetic nephropathy of type 2 diabetes. Methods:、 To investigate diabetes durationfamily hypertention history with questionnaire

determine the 24-hour ambulatory blood pressure

heart rate power spectrum

HbA1c

serum nitric oxide(NO)

plasma lipids and urinary albumin excretionrate (UAER). The patients were divided into diabetic control group and diabetic nephropathy group. To compare the difference among these factors between the two groups and analyze the relationship of these factors and UAER. Results:、、 The 24-hour mean blood pressurediabetes duration family hypertention history

total cholesterol in diabetic nephropathy group were significantly higher than diabetic control group. NO and autonomic nerve function were lower than that of diabetic control. Furthermore

these factors were correlated with UAER. Conclusion: Diabetic nephropathy is the result of multiple factors

such as metabolic disorder

blood pressure elevation

abnormal hemorheology

genetic factor etc

among these blood pressure

diabetes duration and autonomic neuropathy are the main factors to impact on UAER

so the comprehensive prevention actions should be taken to diabetic nephropathy.