Objective: αTo investigate the serum FFA and TNF- levels of the PCOS with insulin resistance 、α(IR)

and the relationship between FFATNF- and the Homa IR. Methods: The serum levels of FFA and TNFα-

in 118 cases of PCOS and 34 cases of non-PCOS but infertility

were determined. According to the results of the fasting blood glucose (FBG) and the fasting insulin levels (FINS)

Homa IR was calculated. Furthermore the cases

who were PCOS with IR

were received rosiglitazone (Avandia) and observed the relevant factors changed after the treatmant. Results: α The levels of FFA and TNF- in the patients of the PCOS group were significantly higher than that in the non-PCOS group (P<0.05). In the patients who received rosiglitazone treatment

the serum αlevels of fasting insulin

fasting C peptide

2h blood glucose

2h insulin

2h C peptide

FFA

TNF-and Homa IR were decreased significantly as compared with those before the treatment (P<0.05

respectively). Conclusion: The αserum FFA and TNF- levels of the PCOS group were higher than the normals

and the two were related positively to Homa IR. FFA and αTNF- can be the criteria of the treatment for the PCOS with IR.