结缔组织生长因子在大鼠心肌梗死后心肌间质重塑中表达的研究

顾永林; 马康华; 罗素新

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结缔组织生长因子在大鼠心肌梗死后心肌间质重塑中表达的研究

更新时间：2024-01-17

- 结缔组织生长因子在大鼠心肌梗死后心肌间质重塑中表达的研究
- Research on expression of CTGF in myocardial interstitial remodeling in infracted rat model
- 重庆医科大学学报 2006年第1期页码：47-49
- 作者机构：
  
  1. 重庆医科大学附属第一医院心内科
  2. 重庆医科大学附属第一医院心内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R542.22
- 纸质出版日期：2006，
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[1]顾永林,马康华,罗素新.结缔组织生长因子在大鼠心肌梗死后心肌间质重塑中表达的研究[J].重庆医科大学学报,2006(01):47-49+131.

GU Yonglin, et al. Research on expression of CTGF in myocardial interstitial remodeling in infracted rat model[J]. Journal of Chongqing Medical University, 2006,(1):47-49.
[1]顾永林,马康华,罗素新.结缔组织生长因子在大鼠心肌梗死后心肌间质重塑中表达的研究[J].重庆医科大学学报,2006(01):47-49+131. DOI：

GU Yonglin, et al. Research on expression of CTGF in myocardial interstitial remodeling in infracted rat model[J]. Journal of Chongqing Medical University, 2006,(1):47-49. DOI：

摘要

目的:探讨心肌梗死后心肌间质重塑中结缔组织生长因子（CTGF）在心肌组织的表达

以进一步探讨心肌重塑的分子机制。方法:SD大鼠24只

随机分为假手术组和心肌梗死组

结扎左冠状动脉前降支建立大鼠心肌梗死后心肌间质重塑模型

假手术组不结扎左冠状动脉

均观察8w。用生物化学方法测定心肌组织胶原蛋白含量以了解心肌间质重塑。用免疫组织化学染色法进行检测分析CTGF表达的变化。用RT-PCR方法检测CTGF m RNA表达的变化。结果:心肌梗死组CTGF蛋白和m RNA表达增强

与假手术组比较有显著性差异（P<0.05）。结论:CTGF与心肌梗死后心肌间质重塑有关

其可能参与心肌梗死后心力衰竭的发展

影响患者预后。

Abstract

Objective: To discuss the expression of CTGF in myocardial tissue during myocardial remodeling and to understand the molecular mechanism of myocardial remodeling after myocardial infarction.Methods: Twenty four SD rats were randomly divided into two groups sham group and infracted group.In infracted group left anterior descending coronary artery was ligated for 8 weeks but not in sham group.Collagen protein of myocardial tissue was tested with chemistry to understand myocardial interstitial remodeling.CTGF protein were studied with immunohistochemistry analysis.CTGF mRNA expression was tested by reverse transcription and polymerase chain reaction(RT-PCR).Results: Expressions of CTGF protein and mRNA were significantly enhanced(P<0.05) in infracted group

as compared with those in sham group.Conclusion: CTGF relates to myocardial interstitial remodeling after myocardial infarction

which may be associated with the development of CHF and prognosis of myocardial infarction.

关键词

结缔组织生长因子心肌梗死间质重塑

Keywords

connective tissue growth factormyocardial infarctionMyocardial interstitial remodeling

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