Objective: to explore the expression and clinical significance of delta N p63 protein in transitional cell carcinoma of the bladder(TCCB).Method: The immunohistochemical staining assay was conducted to detect expression of delta N p63 protein in 43 cases of TCCB and 11 cases of normal bladder epithelium.The relationship between delta N p63 protein expression and pathological types

clinical stages of TCCB was analyzed.Results:The expression rates of delta N p63 protein in TCCB and normal bladder epithelium were 100%(43/43)and 18.2%(2/11)respectively.The difference between the two groups was significant(P<0.05).There was no significant difference in the expression rate of delta N p63 protein in different pathological types and clinical stages of TCCB

The differences between groups were no significant.Conclusion:There is high expression of delta N p63 protein in TCCB

delta N p63 is associated with tumorigenesis in TCCB

but is not associated with pathological types and clinical stages of TCCB.Further studies will be necessary to explore the function of delta N p63 in the progression of TCCB.