Objective: To evaluate the effect and the significance of combined treatment for acute severe pancreatitis complicated with acute respiratory distress syndrome(ARDS) in ICU.Methods: 71 cases of severe acute pancreatitis with ARDS treated in ICU of the hospital where the authors worked from Jan.1996 to Apr.2005 were analyzed retrospectively.Results: GroupⅠwere treated with routine methods and the mechanical ventilation.14 patients died

and the mortality was 48.3%(14/29).Group Ⅱwere treated with routine methods and the mechanical ventilation.All patients were treated with continuous renal replacement therapy(CRRT)

of whom 7 patients were treated with CRRT twice.22 patients were treated with emergent endoscopic retrograde cholangiopancreatography(ERCP)

endoscopic sphincterotomy(EST) and endoscopic naso-bile drainage(ENBD).33 patients were cured and 9 patients died.The mortality was 21.4%(9/42).Conclusion: The combined treatment in ICU can increase the curative effect of the severe acute pancreatitis complicated with ARDS.