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1. 重庆医科大学附属第一医院耳鼻咽喉科
2. 重庆医科大学附属第一医院耳鼻咽喉科,重庆,400016
纸质出版日期:2006,
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[1]方小云,余林.阻塞性睡眠呼吸暂停低通气综合征患者耳蜗功能的研究[J].重庆医科大学学报,2006(02):243-245+255.
FANG Xiaoyun, et al. Cochlear function in patients with obstructive sleepapnear-hypopnea syndrome[J]. Journal of Chongqing Medical University, 2006,(2):243-245.
目的:通过观察阻塞性睡眠呼吸暂停低通气综合征患者(OSAHS)的听性脑干反应(ABR)测试结果评价OSAHS患者的耳蜗功能变化。方法:收集本院耳鼻咽喉科2004年2月至2004年9月40例符合本研究纳入标准的OSAHS住院病例
根据AHI结果将全部病例分为轻度OSAHS组(5≤AHI≤20)和中重度OSAHS组(AHI>20)进行ABR测试。记录ABR波Ⅰ、Ⅲ、Ⅴ潜伏期
波Ⅰ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ波间期。比较轻度OSAHS组和中重度OSAHS组患者各波潜伏期和波间期与正常对照值之间的差异。结果:中重度OSAHS组患者ABR的波Ⅰ、Ⅲ、Ⅴ潜伏期及波Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期比正常对照值延长
差异具有显著性(P<0.05);与轻度OSAHS组相比
中重度OSAHS组患者ABR的波Ⅰ、Ⅲ潜伏期延长
差异具有显著性(P<0.05);轻度OSAHS组患者各波潜伏期和波间期与正常对照值相比无统计学意义改变(P>0.05)。结论:反复发作的中重度OSAHS能够损害耳蜗功能
且OSAHS对耳蜗功能的影响是一个渐进的过程。ABR可以作为OSAHS是否影响耳蜗功能的一项监测指标。
Objective: To investigate the cochlear function of the patients suffering from obstructive sleep apnea-hypopnea syndrome(OSAHS) by using ABR.Methods: 40 patients with OSAHS(80 ears) admitted from February 2004 to September 2004 were divided into two subgroups: mild OSAHS group(11 cases) and moderate and severe OSAHS group(29 cases)according to the value of AHI.Each group was tested by Auditory brainstem response(ABR).The latencies of wave Ⅰ、Ⅲ、Ⅴand the interpeak latency intervals of waveⅠ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴ were measured.The obtained results of the two subgroups were respectively compared with the normal values.Results: The latencies of waveⅠ、Ⅲ、Ⅴ and the interpeak latency intervals of wave Ⅰ-Ⅲ、Ⅰ-Ⅴin the moderate and severe OSAHS subgroup were prolonged compared with the normal control values
and the difference was significant statistically.The latencies of waveⅠ、Ⅲ in the moderate and severe OSAHS subgroup were significantly prolonged compared with those in the mild OSAHS subgroup.But there was no statistical change in the latencies of wave Ⅰ、Ⅲ、Ⅴand the interpeak latency intervals of waveⅠ-Ⅲ、Ⅲ-Ⅴ、Ⅰ-Ⅴin the mild OSAHS subgroup as compared with the normal control values.Conclusion: Cochlear function can be impaired in patients with moderate and severe OSAHS
and ABR can be taken as a monitor index to observe whether OSAHS affects cochlear function or not.
听性脑干反应耳蜗功能阻塞性睡眠呼吸暂停低通气综合征
Auditory brainstem response(ABR)Cochlear functionObstructive sleep apnea-hypopnea syndrome(OSAHS)
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