WU Yu, et al. Effect of inhalable particulate matter from roadside dust on airway inflammation in rats[J]. Journal of Chongqing Medical University, 2007,(1):62-64.
WU Yu, et al. Effect of inhalable particulate matter from roadside dust on airway inflammation in rats[J]. Journal of Chongqing Medical University, 2007,(1):62-64.DOI：
Objective:To study the effect of roadside dust inhalable particulate matter on airway inflammation in rats.Methods:Particles at roadside were collected
analyzed and PM10-treat model of rats were established.Lung tissue histopathology was observed.The counts of total leukocytes and neutrophils in bronchoalveolar lavage fluid(BALF)and superoxide dismutase(SOD)
glutathion peroxidase(GSH-Px)
malondiadehyde(MDA)
cytokin-induced neutrophil chemotactics(CINC)in lung homogenate were measured.Results:The counts of total leukocytes
macrophages and neutrophils in PM10-treat group were increased significantly than those in control group(P<0.05).The pathological changes of roadside dust group indicated that it could cause airway injury.Conclusion:The mechanism of the airway inflammation by IP is complicated.The terminal way is inflammatory reaction by inflammatory cells and cell factors.
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