Objective: To study the effect of probucol on pancreatic β-cells in STZ-induced diabetes mice.Methods: The mice were randomly divided into four groups with ten mice in each group.The first group was given standard food(C group)

The second group given standard food and 1% probucol(C+T group).The third group given standard food and treated with multiple low-dose of STZ(D group)

and the forth group given standard food

1% probucol as well as treated with multiple low-dose of STZ(D+T group).The preventive intervention was undertaken with standard diet mixed with 1% probucol in Kunming mice.At different time after STZ was injected intraperitoneally

fasting blood glucose was measured.Serum insulin and glucose tolerance test was done.The pancreatic pathological changes were investigated under light microscope.Results: The fasting blood glucose at 0

1

2

3 weeks in D+C group was lower than that in D group(P<0.05 or P<0.01).At 3 weeks in D+C group glucose tolerance was significantly improved(P<0.05 or 0.01) and compared with the D group

serum fasting insulin in D+C group was increased(P<0.01).Conclusion: Probucol could reduce fasting blood glucose and improve glucose tolerance by protection of pancreatic β-cells in STZ-induced diabetes mice.