Objective: To study the expression and significance of apoptosis related gene survivin in meningiomas.Methods: The expression of survivin protein was detected by immunohistochemical method(SP) in 60 cases of meningiomas
and its relationship with pathological parameters was analyzed.Results: The expression rate of survivin protein in meningioma of Ⅰ
Ⅱand Ⅲ grade were 32.0%
60.0% and 86.7% respectively
and there were great differences among the three groups(P<0.05).The positive ratio was closely correlated with aggressive behavior and peritumoral edema(P<0.05).Conclusions: The expression of survivin in meningiomas was closely correlated and increased with its malignancy.Survivin may play an important role in pathogenesis of malignant meningiomas.