Objective:To investigate the changes of monoamine oxidase B(MAO B)activity in variety of neurodegenerative animal models and to discuss their significance.Methods:The neurodegenerative models were built with NIH male mice by means of the cerebral ischemia-reperfusion

aluminum overloading and carbon monoxide intoxication

respectively.The learning and memory ability of mice

MAO B activity of brain homogenates

and pathomorphological changes of hippocampal slices were determined using Morris maze and Step-down tests

MAO B kit

as well as microscopic observation with HE stain.Result:Although the significantly decreasing learning and memory ability and loss and karyopyknosis of hippocampal neurons were observed in three groups of animal models

compared with control group

the changes of MAO B activity were quite different.There was no significant change in cerebral ischemia-reperfusion model

but the unusual elevation was found in both aluminum overloading model and carbon monoxide intoxication model.Conclusion:The abnormal increase of MAO B does not occur in a variety of neurodegenerative animal models

which may indicate that the cerebral ischemia-reperfusion model can be used in the research of dementia and aluminum overloading model and carbon monoxide intoxication model can be used in the research of both dementia and extrapyramidal disease.