特异性环氧化酶-2抑制剂对狼疮小鼠肾组织PAI-1表达的影响

钟清; 甘华; 肖刚

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特异性环氧化酶-2抑制剂对狼疮小鼠肾组织PAI-1表达的影响

更新时间：2024-01-17

- 特异性环氧化酶-2抑制剂对狼疮小鼠肾组织PAI-1表达的影响
- Influence of specific cyclooxygenase-2 inhibitor on the expression of plasminogen activator inhibitor type-1 in lupus MRL/lpr mice.
- 重庆医科大学学报 2006年第1期页码：63-65
- 作者机构：
  
  1. 重庆医科大学附属第一医院肾内科
  2. 重庆医科大学附属第一医院肾内科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：
  中图分类号： R593.242
- 纸质出版日期：2006，
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[1]钟清,甘华,肖刚.特异性环氧化酶-2抑制剂对狼疮小鼠肾组织PAI-1表达的影响[J].重庆医科大学学报,2006(01):63-65+77.

ZHONG Qing, et al. Influence of specific cyclooxygenase-2 inhibitor on the expression of plasminogen activator inhibitor type-1 in lupus MRL/lpr mice.[J]. Journal of Chongqing Medical University, 2006,(1):63-65.
[1]钟清,甘华,肖刚.特异性环氧化酶-2抑制剂对狼疮小鼠肾组织PAI-1表达的影响[J].重庆医科大学学报,2006(01):63-65+77. DOI：

ZHONG Qing, et al. Influence of specific cyclooxygenase-2 inhibitor on the expression of plasminogen activator inhibitor type-1 in lupus MRL/lpr mice.[J]. Journal of Chongqing Medical University, 2006,(1):63-65. DOI：

摘要

目的:探讨特异性环氧化酶（COX）-2抑制剂（Rofecoxib）对M RL/lpr自发狼疮小鼠肾脏纤溶酶原激活物抑制剂-1（PAI-1）表达的影响。方法:12w龄雌性M RL/lpr自发狼疮小鼠予以Rofecoxib[10m g/（kg.d）]灌胃治疗

12w后观察Rofecoxib对小鼠尿蛋白、血肌酐的影响。放免法测定血清血管紧张素II、尿TXB2、尿6-Ket-F1α的水平;用免疫组化方法观察小鼠肾组织PAI-1的表达及肾组织病变程度

并与对照组比较。结果:治疗12w后

治疗组与对照组相比:尿蛋白排泄量、肌酐水平、血管紧张素II及尿TXB2水平均有明显下降

差异有显著性;肾组织细胞外基质的沉积明显减少及肾组织PAI-1的表达降低（P<0.05）;尿6-Ket-F1α差异无显著性（P>0.05）。结论:特异性COX-2抑制剂可以抑制M RL/lpr自发狼疮小鼠肾组织PAI-1的表达

降低尿蛋白

减少细胞外基质的沉积

从而减轻肾小球硬化

对狼疮性肾炎肾损害具有良好的治疗作用。

Abstract

Objective: To explore the effect of specific cyclooxygenase-2 inhibitor(Rofecoxib) on the expression of plasminogen activator inhibitor type-1 in MRL/lpr mice.Methods: 12-week female MRL/lpr mice were given Rofecoxib[10mg/(kg·d)] for 12 weeks.Changes in proteinuria

serum creatinine and pathology in renal were observed.Suppressive effect of the drugs on angiotensin II and urinary thromboxane B2 and 6-Keton-prostaglandin-F1α were determined by using radio-immunological assay.Immunolhistological analysis was used to examine the expression of PAI-1 in renal tissue.Results : Compared with the ones in the control group

mice treated with Rofecoxib had lower levels of proteinuria

serum creatinine

serum angiotensin II

urinary thromboxanc B2(P<0.05).The PAI-1 expression and deposition of extracellular matrix in renal tissue significantly decreased(P<0.05).The level of 6-Keton-prostaglandin-F1α was not significantly different(P>0.05).Conclusion: Rofecoxib may decrease proteinuria and ameliorate progressive glomerular sclerosis by inhibiting partly the expression of PAI-1 by decreasing the deposition of extracellular matrix and accelerating its degradation.The specific cyclooxygenase-2 inhibitor has a renoprotective effect on MRL-lpr/lpr mice.

关键词

特异性环氧化酶-2抑制剂纤溶酶原激活物抑制剂-1狼疮肾炎

Keywords

specific cyclooxygenase-2 inhibitorplasminogen activator inhibitor type-1lupus nephritis

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